Validation of bioinformatic approaches for predicting allergen cross reactivity
نویسندگان
چکیده
منابع مشابه
Bioinformatic Approaches for Predicting substrates of Proteases
Proteases have central roles in "life and death" processes due to their important ability to catalytically hydrolyze protein substrates, usually altering the function and/or activity of the target in the process. Knowledge of the substrate specificity of a protease should, in theory, dramatically improve the ability to predict target protein substrates. However, experimental identification and ...
متن کاملAssessment of allergen cross-reactivity
The prediction of allergen cross-reactivity is currently largely based on linear sequence data, but will soon include 3D information on homology among surface exposed residues. To evaluate procedures for these predictions, we need ways to quantitatively assess actual cross-reactivity between two allergens. Three parameters are mentioned: 1) the fraction of the epitopes that is cross-reactive; 2...
متن کاملCross-React: a new structural bioinformatics method for predicting allergen cross-reactivity
The phenomenon of cross-reactivity between allergenic proteins plays an important role to understand how the immune system recognizes different antigen proteins. Allergen proteins are known to cross-react if their sequence comparison shows a high sequence identity which also implies that the proteins have a similar 3D fold. In such cases, linear sequence alignment methods are frequently used to...
متن کاملBioinformatics approaches to classifying allergens and predicting cross-reactivity.
Allergenic proteins from very different environmental sources have similar sequences and structures. This fact may account for multiple allergen syndromes, whereby a myriad of diverse plants and foods may induce a similar IgE-based reaction in certain patients. Identifying the common triggering protein in these sources, in silico, can aid designing individualized therapy for allergen sufferers....
متن کاملCommentary Assessment of allergen cross - reactivity
The prediction of allergen cross-reactivity is currently largely based on linear sequence data, but will soon include 3D information on homology among surface exposed residues. To evaluate procedures for these predictions, we need ways to quantitatively assess actual cross-reactivity between two allergens. Three parameters are mentioned: 1) the fraction of the epitopes that is cross-reactive; 2...
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ژورنال
عنوان ژورنال: Food and Chemical Toxicology
سال: 2019
ISSN: 0278-6915
DOI: 10.1016/j.fct.2019.110656